肝硬化并反流性食管炎的临床、内镜及病理分析
...色检查,亦按1999年烟台标准进行分级。鳞状上皮增生、炎细胞浸润为轻度,出现黏膜糜烂为中度,有溃疡形成或Barrett食管改变为重度。 1.4统计学处理采用χ2检验。 2结果 2.1内镜检查结果RE内镜下表现为黏膜点状或条状...
医源资料库;在线期刊;滨州医学院学报;2007年第30卷第5期核因子κB的结构和功能与内毒素介导的肝损伤的关系
...ppaB(NF-κB)是近年来研究极为广泛的核内转录调控因子,在细胞炎性反应、免疫反应以及细胞凋亡等过程中起着举足轻重的作用。NF-κB参与多种细胞因子及急性期反应蛋白转录活性的调控,在免疫和炎性疾病的启动中起重要作用。...
医源资料库;在线期刊;中华现代中西医杂志;2010年第8卷第1期GeneticDiversityandRecombinationofPorcineSapoviruses
...manstrainsexist.INTRODUCTIONSapoviruses(SaV),previouslyreferredtoasSapporo-likeviruses,areemergingentericpathogensthatcausediarrheainhumans,pigs,andmink(5,7,9,10,22).Theyarenonenveloped,polyadenylatedsingle-strandedpositive-senseRNAvirusesandbelongtotheSapovirusgenusinthefamilyCaliciviridae(7).TheSa...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期SensitiveEDTA-BasedMicrobiologicalAssaysforDetectionofMetallo--LactamasesinNonfermentativeGram-NegativeBacteria
...othecrudeextracts10minbeforeperformingtheassay.ThepresenceofthegenesblaVIM-like,blaIMP-like,andblaSPM-1(forbothPseudomonasspp.andA.baumannii)andblaL1-like,blaIND-like,andblaGOB-like(forStenotrophomonasmaltophilia,Chryseobacteriumindologenes,andChryseobacteriummeningosepticum,respectively)wasanalyzed...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期DevelopmentofaMultiplexPCRandSHVMelting-CurveMutationDetectionSystemforDetectionofSomeSHVandCTX-M-LactamasesofEscherichiacoli,Klebsiella
...mentofanovelsystem,whichconsistsofamultiplexPCRtoidentifyblaSHV,blaCTX-M-3-like,andblaCTX-M-14-likegenesandamodifiedSHVmelting-curvemutationdetectionmethodtorapidlydistinguishsixprevalentblaSHVgenes(blaSHV-1,blaSHV-2,blaSHV-2a,blaSHV-5,blaSHV-11,andblaSHV-12)inTaiwan.Sixty-fiveclinicalisolates,which...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期一种新型的polo-like激酶途径调节剂ON01910.Na在成人实体瘤治疗的I期临床试验
SOURCE:JournalofClinicalOncology一种新型的polo-like激酶途径调节剂ON01910.Na对成人实体瘤患者进行了I期临床试验,旨在确定其剂量限制性毒性(dose-limitingtoxicities,DLTs)。20例(11女,9男)难治性(针对常规治疗)实体瘤患者纳入研究,...
行业资讯;临床快报;肿瘤相关VacciniavirusproteinA46RtargetsmultipleToll-like–interleukin-1receptoradaptorsandcontributestovirulence
...tkeyaspectsofthehostantiviralresponse.Recently,ithasbeenrecognizedthatToll-likereceptors(TLRs)havearoleininnatedefenseagainstviruses.Here,wedefinethefunctionofthevacciniavirus(VV)proteinA46RandshowitinhibitsintracellularsignallingbyarangeofTLRs.TLRsignallingistriggeredbyhomotypicinteractionsbetweent...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期MolecularCharacterizationsofHumanandAnimalGroupARotavirusesinTheNetherlands
...peG8wasnotfound.GenotypeG6bovinerotavirusesweredividedintothreeclusters:UK-like,VMRI-29-like,andHun4-like.DNAsequencingofapartoftheVP7genewasshowntobeusefulasaquickdeterminationofuncommonornovelstrainsofwhichthegenotypingcannotbedonebygenotypingPCR.Ofequinestrains,bothVP4andVP7genescouldbeusedforgen...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期SerumAmyloidAInducesContraryImmuneResponsesviaFormylPeptideReceptor-Like1inHumanMonocytes
...rTNF-andIL-10production,respectively.Thestimulationofformylpeptidereceptor-like-1-expressingRBL-2H3cells,butnotofvector-expressingRBL-2H3cellswithserumamyloidA,inducedmitogen-activatedproteinkinasesactivationandtheaccumulationoftheRNAsofthesetwocytokines.Together,ourfindingssuggestthatserumamyloidAm...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期Opioidreceptor-like1stimulationinthecollectingductinducesaquaresisthroughvasopressin-independentaquaporin-2downregulation
...ociceptin,theendogenousligandoftheinhibitoryGprotein-coupledopioidreceptor-like1receptor,producesaquaresis(i.e.,increasestheexcretionofsolute-freeurine)inrats.However,themechanismunderlyingthiseffecthasnotyetbeenexplained.Usingimmunohistochemistry,wefoundtheopioidreceptor-like1receptorintheratkidney...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第7期